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Thus, sesquiterpene lactone cynaropicrin induces a rapid drop in intracellular GSH levels, thereby triggering S-glutathionylation of STAT3 and the suppression of anti-apoptotic genes, Bcl-2, and survivin in DU145 human prostate adenocarcinoma cells, leading to cell death through apoptosis and potentiation of the cytotoxic effects of cisplatin and docetaxel [295]

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The first section of this review focuses on the genesis and historical development of INH along with various known (validated as well as non-validated) mechanisms of action contributing to the overall anti-tubercular activity of INH